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Discapacidad

“In the flesh”: Narratives of family caregivers at risk of Early-onset Familial Alzheimer’s Disease

06/03/2023
Documentación

In the growing body of literature dealing with the consequences of family caregiving amongst people with dementia, there are few studies examining the impact of Early-onset Familial Alzheimer’s Disease on caregivers. This study exposes the subjective experience of a group of family caregivers who themselves possess a genetic susceptibility to develop this form of dementia. […]

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Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density

06/03/2023
Documentación

ObjectivesTo identify genetic determinants of susceptibility to clinical vertebral fractures, which is an important complication of osteoporosis.MethodsHere we conduct a genome-wide association study in 1553 postmenopausal women with clinical vertebral fractures and 4340 controls, with a two-stage replication involving 1028 cases and 3762 controls. Potentially causal variants were identified using expression quantitative trait loci (eQTL) […]

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Using Exploratory Structural Equation Modeling (ESEM) to Examine the Internal Structure of Posttraumatic Stress Disorder Symptoms

06/03/2023
Documentación

Abstract Several studies have reported the factor structure of posttraumatic stress disorder (PTSD) using confirmatory factor analysis (CFA). The results show models with different number of factors, high correlations between factors, and symptoms that belong to different factors in different models without affecting the fit index. These elements could suppose the existence of considerable item […]

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