The Rose F. Kennedy Intellectual and Developmental Disabilities Research Center (RFK IDDRC) and its programs represent the hub of Einstein’s research labs and patient clinics focused on intellectual and developmental disabilities (IDDs). Founded more than 40 years ago, the RFK IDDRC has long been at the forefront of research on normal and abnormal brain development and function, and of clinical care for children with IDDs. Today, with reinvigorated leadership, the RFK IDDRC is dissolving barriers between neuroscience and genetic research; fostering new and productive collaborations between basic scientists and clinicians; and advancing knowledge about and treatments for IDDs impacting children.