The Alpha One International Registry (AIR) is a multinational research organization, representing a combined research effort of nearly 20 countries. It was formed in response to a recommendation of the World Health Organization at a meeting on alpha1-antitrypsin (AAT) deficiency in March 1996.

Representatives from the member countries meet at least twice per year during a council meeting to discuss AAT research and the progress of AIR. A Coordinating Committee is responsible for the management of the group.