Sexual coercion is a worldwide health problem that endangers the well-being of those involved. In the same line of the most recent and comprehensive studies, this study sought to investigate the extent of sexual coercion, both perpetration and victimization, among male and female adolescents. Moreover, it jointly analyzed the predictive power of different variables that have been considered as useful to design preventive programs. For this purpose, a cross-sectional study, using proportional stratified cluster sampling, was performed and 1,242 Spanish adolescents (15-19 years old) were surveyed. Results show that both genders had reported committing and suffering sexual coercion. However, perpetration was reported more often by males: no significant gender difference was found in victimization. It was also concluded that need for control and power, normative beliefs about sexual coercion, hostile sexism, negative alcohol expectancies, and sociosexual orientation were significant predictors of perpetration for both genders. Concerning victimization, need for control and power and normative beliefs were found to be significant predictors for males and females, as were negative alcohol expectancies and sexual esteem, though only for males. According to these results, both genders can be both perpetrators and victims of sexual coercion in adolescence, but not to the same extent. Moreover, preventive programs should include activities related to perpetration and victimization, taking into account the effectiveness of their components to intervene with male and female adolescents.